Analgesic Ceiling Effect
As with all nsaids the drug has an analgesic ceiling the dose at which additional dosing will not provide additional analgesia but can lead to more side effects.
Analgesic ceiling effect. The analgesic ceiling effect of nonsteroidal anti inflammatory drugs nsaids is well studied. The ceiling effect is the concept that there exists a dose beyond which there is no additional analgesic benefit. The correlation between blood levels of ibuprofen and clinical analgesic response. The term ceiling effect has two distinct meanings referring to the level at which an independent variable no longer has an effect on a dependent variable or to the level above which variance in an independent variable is no longer measured or estimated.
You can see how lumping all of these studies together in a review would misconstrue pretty much any endpoint. Mixed agonist antagonist opioids such as nalbuphine serve as a classic example of the ceiling effect. Although ibuprofen is commonly used in dosages as high as 800 mg for acute pain. The risk of gi bleeding appears to be related to the use of higher doses and prolonged use.
Laska em et al. In pharmacology the term ceiling effect refers to the property of increasing doses of a given medication to have progressively smaller incremental effect an example of diminishing returns.
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